Expression of FHITmRNA and WWOXmRNA in human breast cancer and their clinical significance

VernacularTitle:FHITmRNA和WWOXmRNA在乳腺癌中的表达及其临床意义
Author: Tiantian WANG ; Rong MA ; Haidong GAO ; Lubing TANG ; Jinbo FENG
Publication Type:Journal Article
Keywords: Breast Neoplasms/pathol; Gene, WWOX; FHIT
From: Chinese Journal of General Surgery 2001;0(09):-
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of FHITmRNA and WWOXmRNA in human breast cancer tissues and its relation to clinicopathological and other molecular parameters. Methods With reference to the expression of ?-actin,the expression of FHITmRNA and WWOXmRNA was determined by reverse (transcription)-polymerase chain reaction(RT-PCR) in 51 breast cancer and adjacent breast tissue, and (semi-quantitative) analysis of band densities was performed. The protein expression of estrogen receptor(ER), progesterone receptor (PR), Her-2 gene in the 51 breast cancer lesions was detected by (immunohistochemical) method. Results FHITmRNA and WWOXmRNA expression was significantly different in 54 breast cancer tissue compared to adjacent breast tissue (P0.05); of FHITmRNA and WWOX mRNA was related to axillary lymph node metastasis (P