Effect of prone-position ventilation on oxygenation in patients with acute respiratory distress syndrome
- VernacularTitle:俯卧位通气下急性呼吸窘迫综合征患者氧合的变化
- Author:
Ling LIU
;
Yingzi HUANG
- Publication Type:Journal Article
- Keywords:
Prone position;
Respiration, artificial;
Respiratory distress syndrome, adult;
Pulmonary gas exchange
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of prone position (PP) ventilation on oxygenation in patients with acute respiratory distress syndrome (ARDS) .Methods Twenty-three patients of both sexes (14 males, 9 females) with ARDS (within 72 h after onset of ARDS) were included in this study. The patients ranged in age from 43-78 years. Ten minutes before the patients were placed in prone position, midazolam 2-5 mg was given i. v. followed by continuous infusion at 2-3 mg?h-1 for sedation and a bolus of vecuronium 4 mg per hour for muscle relaxation. The patients were mechanically ventilated (VT 6-8 ml?kg-1, inspiration-time 1.0-1.2 s, RR 12-20 bpm, FiO2 0.4-1.0, PEEP 6-18 cm H2O) . The patients were placed in prone position for 2 h. Radial artery was cannulated and S-G catheter placed. MAP, CVP, MPAP, PAWP, cardiac output, PaO2 , PaCO2 peak inspiratory pressure (PIP) and airway resistance (Raw) were measured and recorded immediately before (T0) and 0.5, 2 h after the patients were placed in prone position (T1 , T2) and 2 h after supine position was resumed(T3) . PaO2/FiO2 and static compliance of the respiratory system (Cst) were calculated. Results In 87% of the patients PaO2/FiO2 was significantly increased during prone position (T1, T2) as compared to the baseline (T0) (P
