Diazoxide pretreatment protects primarily cultured hippocampal neurons against anoxia/reoxygenation injury
- VernacularTitle:二氮嗪预先给药对原代培养大鼠海马神经元缺氧/复氧损伤的保护机制
- Author:
Bin ZHU
;
Tiehu YE
- Publication Type:Journal Article
- Keywords:
Diazoxide;
Cell hypoxia;
Hippocampus;
Neurons
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of pharmacological preconditioning with diazoxide, an ATP-sensitive potassium channel opener, against anoxia/reoxygenation (A/R) injury to primarily cultured hippocampal neurons of newborn Wistar rats and the mechanism involved and the effects of diazoxide preconditioning on A/R-induced neuronal apoptosis. Methods Primarily cultured hippocampal neurons prepared by enzymatic digestion of hippocampus isolated from newborn (
