Protective Role of Anisodamine Against Rabbit Liver Injury by Hemorrhage Shock Complicated with Endotoxemia and the Underlying Mechanism
- VernacularTitle:山莨菪碱对兔失血性休克合并内毒素血症诱发肝脏损伤的保护机制研究
- Author:
Jian LIU
;
Wen YIN
;
Shunshu YUAN
- Publication Type:Journal Article
- Keywords:
Anisodamine;
Hemorrhage Shock;
Liver Injury;
HSP70;
NF-?B
- From:
Journal of Chinese Physician
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the possible protective mechanisms of Anisodamine against liver injury induced by hemorrhage shock(HS). Methods In this study, we established animal models induced by HS and endotoxin, observed the expressions of NF-?B mRNA and heat shock protein 70(HSP 70) mRNA by In-situ hybridization (ISH) in liver kupffercells(KC) and studied the pathologic changes of the liver tissue by microscope. Results After stimulus of HS and injection of endotoxin, the mRNA expressions of HSP70 and NF-?B in KC were (0.1565?0.0260) and (0.1659?0.0103),respectively, and significantly higher than those in the control group (0.0328?0.0201; 0.0256?0.0043)(P
