Effect of hyperthermia on VX_2 carcinoma bearing rabbits
- VernacularTitle:热疗对荷VX_2瘤动物细胞因子影响的实验研究
- Author:
Weizhen YANG
;
Jiwei WEI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Di athermy;
Tumor necrosis factor;
Interleukin
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hype rt hermia on cytokines of VX_2 carcinoma bearing rabbits. Method Forty healthy male rabbits were randoml y divided into heat therapy group and control group. Rabbits in heat therapy gro up underwent hyperthermia 11 days after inoculated with VX_2 cells. IL-2, tumor necrosis factor (TNF) and insulinlike growth factor (IGF) were measured b efore and after heat therapy. Results In heat therapy group survival was prolonged for 15 days. IL-2 d ecreased gradually from (134?6)ng/ml before heat therapy, (81?7)ng/ml one week after, (61.8?2.0)ng/ml at 3 weeks, and (54.8?2.6)ng/ml at 4 weeks along with an increase of TNF and IGF (4.5?0.9)ng/ml, and ( 96?28)ng/ml; (7.6?1.8)ng/ml and (678?183)ng/ml; (15.1?3 .0)ng/ml and (991?108)ng/ml; (17.2?2.1)ng/ml and (1136?89 )ng/ml respectively at the corresponding time period. Conclusion Heat therapy is effective for the tre atment of superficial tumors probably through a mechanism of antigen-antibody r eaction.
