Study on the Blood Concentration of Fluorouracil Administered into Guinea Pigs by Arterial&Intravenous Infusion and Celiac Infusion
- VernacularTitle:氟尿嘧啶经豚鼠动脉、静脉与腹腔给药后的血药浓度变化
- Author:
Rong CHEN
;
Xueqin ZHOU
;
Changjie GUO
- Publication Type:Journal Article
- Keywords:
Arterial infusion;
Intravenous infusion;
Celiac infusion;
Blood concentration
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare and analyze blood concentration changes of fluorouracil administered to guinea pigs by different paths.METHODS:The peripheral vein and portal vein blood samples of guinea pigs were taken at different time after administered with fluorouracil in3different ways:group A(by arterial infusion),group B(by intravenous infusion)and group C(by celiac infusion).The blood concentration changes were determined and analyzed by HPLC.RESULTS:The portal vein and peripheral vein blood concentrations in group A and B reached peak value5min after administration with flu?orouracil while group C reached peak at10min;the portal vein blood concentrations in group A reached the highest in the first20min while group C showed the highest value in the last30min.CONCLUSION:Arterial infusion combining celiac infusion path was recommended for local chemotherapy;arterial infusion combining intravenous infusion or intravenous infusion com?bining celiac infusion was recommended for the local therapy while giving consideration to systemic chemotherapy.
