Determination of the Related Substances in Etodolac Sustained Released Tablets by HPLC
- VernacularTitle:高效液相色谱法测定依托度酸缓释片中的有关物质
- Author:
Wanhua YANG
- Publication Type:Journal Article
- Keywords:
HPLC;
Etodolac sustained released tablets;
Related substances
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish HPLC method in the determination of the related substances in etodolac sustained released tablets.METHODS:The determination was performed with C 18 as the chromatographic column.The mobile phases consisted of methanol-acetonitrile-0.055mol/L ammonium acetate solution(60∶40∶900)and methnol-acetonitrile-0.5mol/L ammonium acetate solution(540∶360∶100),which were subjected to gradient elutions.Its flow rate of was1.0ml/min,the column temperature was35℃,the detection wavelength was220nm and the sample size was10?l.RESULTS:The main peaks of etodolac and the other peaks of the related foreign substances could be well isolated in all the specificity tests.The determination of the related substances of the3batches of samples can satisfy the determination requirements for the related substances in etodolac sustained released tablets.CONCLUSION:This method can be applied to determine the related sub?stances in etodolac sustained released tablets.
