Effects of Acitretin on Angiogenesis induced by Vascular Endothelial Growth Factor (VEGF) in Patients with Psoriasis
- VernacularTitle:阿维A治疗前后对银屑病患者血管内皮生长因子表达的影响
- Author:
Ju WEN
;
Quan LUO
;
Xibao ZHANG
;
Zhongfang LIN
- Publication Type:Journal Article
- Keywords:
Acitretin;
Psoriasis;
Endothelial growth factors;
Neovascularization;
pathologic;
Micro-vascular density
- From:
Chinese Journal of Dermatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of effects of acitretin on the treatment of psoriasis. Methods The expression of vascular endothelial growth factor (VEGF) and micro-vascular density (MVD) were detected by immunohistochemical technique before and after treatment with acitretin in 32 patients with psoriasis. Serum level of VEGF was measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The expression of VEGF protein and MVD were significantly higher in psoriatic lesions before treatment with acitretin than those after treatment (P
