Study on Methylation Status of pl6 Gene in PBMC of Patients with Plaque Psoriasis
- VernacularTitle:斑块状银屑病外周血单一核细胞p16基因甲基化状态的研究
- Author:
Jiang JI
;
Pangen CUI
;
Min CHEN
;
Yumei LI
;
Jingbing LI
;
Zhiqiang CHEN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Genes,p16;
Methylation
- From:
Chinese Journal of Dermatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the methylation status of p16 gene in peripheral blood mononuclear cell (PBMC) of patients with plaque psoriasis, and to study its significance in the pathogenesis of the disease. Methods Thirty-four cases of psoriatic patients and 35 healthy controls were measured for the status of promoter methylation in p16 gene by methylation specific PCR (MSP). A region containing CpG site in p16 gene promoter was amplified by MSP. The severity of psoriasis was evaluated by PASI scores. Results The methylation rates of p16 gene in PBMC were significantly higher (P
