Study on the Bioequiavailability of Zolmitriptan Tablets in Human Body
- VernacularTitle:佐米曲普坦片的人体生物等效性研究
- Author:
Ling TAN
- Publication Type:Journal Article
- Keywords:
Zolmitriptan;
HPLC-fluorometric method;
Bioequiavailability
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the bioavailability of the domestic and the imported zolmitriptan tablets in human body.METHODS:The plasma concentration of zolmitriptan in24healthy male volunteers were determined by HPLC-FI after o?rally administered with single dose of5mg zolmitriptan tablets by randomized crossover way,the pharmacokinetics parameters and the relative bioavailability of which were calculated.RESULTS:The plasma concentration-time curves of the oral zolmitriptan tablets fitted one-compartment open model of linear dynamics,the main parameters of domestic tablets and im?ported tablets were described as follows,C max (8.273?3.379)ng/ml and(7.756?2.623)ng/ml,t max (2.341?1.169)h and(2.644?1.121)h,AUC 0～t (47.95?15.75)(ng?h)/ml and(46.27?13.71)(ng?h)/ml,the relative bioavailability of do?mestic zolmitriptan tablets and the imported tablets was(106.72?32.03)%.CONCLUSION:The domestic and the imported zomitriptan tablets is bioequivalent.
