Study on Bioequiavailability in Human Body between Domestic and Imported Roxithromycin
- VernacularTitle:国产与进口罗红霉素片的人体生物等效性研究
- Author:
Yubing ZHU
;
Dawei XIAO
;
Jianjun ZOU
;
Wei QIAN
;
Yunfang HU
;
Cuixia YU
;
Rong GU
- Publication Type:Journal Article
- Keywords:
Roxithromycin;
LC-MS;
Bioequiavailability
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the bioequiavailability of domestic roxithromycin tablets and imported ones.METH?ODS:20male healthy volunteers took single dose of150mg roxithromycin tablet orally in a random crossover design,blood concentrations were determined by LC-MS.RESULTS:The main pharmacokinetic parameters of domestic and imported tablets were determined respectively as follows,AUC 0～72 were(72.81?23.85)(mg?n)/L and(72.63?20.86)(mg?h)/L,AUC 0～∞ were(74.41?24.45)(mg?h)/L and(74.42?24.45)(mg?h)/L,C max were(6.46?1.51)mg/L and(6.58?1.55)mg/L,t max were(1.9?0.5)h and(1.8?0.5)h,t 1/2 were(13.56?1.35)h and(14.18?1.50)h,the relative bioavailability of the homemade tablet to imported one was(99.8?11.2)%.CONCLUSIONS:Domestic and imported roxithromycin are bioequivalent.
