Effect of Yangyu Tuji on content of type Ⅰ, Ⅲ collagen and the expression of MMPs and TIMP-1 in wound caused by streptozotocin in rats
- VernacularTitle:疡愈涂剂对糖尿病大鼠创面Ⅰ、Ⅲ胶原合成及MMPs、TIMP-1表达的影响
- Author:
Xun SHENG
;
Guangshan LI
;
Ping LI
;
Fang WANG
;
Daiying LIANG
;
Xin LIU
;
Qifu HUANG
- Publication Type:Journal Article
- Keywords:
Collagen type Ⅰ;
Collagen type Ⅲ;
Matrix metalloproteinases;
Diabetes mellitus;
Tissue inhibitor of metalloproteinases-1
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of Yangyu Tuji (YYTJ) on delayed healing wound of diabetic rats caused by streptozotocin (STZ). METHODS: SD male rats were randomly divided into control group (control), model group (model); and 3 different dose groups of YYTJ. 55 mg/kg STZ were given by intraperitoneal injection except for control group. After 30 days, a round skin of 1.6 cm diametre was excised on all dorsal back of rats. The healing time and healing rate were observed according to re-epithelization. The content of collagenⅠ and Ⅲ was observed by Picric acid-Sirius red staining , Matrix metalloproteinase-1, 13 (MMP-1, -13), tissue inhibitor of metalloproteinases-1 (TIMP-1) by immuno-histochemistry assay. All data were analyzed by IPP software. RESULTS: The healing time in each group treated with YYTJ was shorter than that in model group (P
