Time window of bone marrow stem cell homing to ischemia myocardium after acute myocardial infarction in rats
- VernacularTitle:大鼠急性心肌梗死后骨髓干细胞归巢于缺血心肌的时间窗研究
- Author:
Chun YANG
;
Aiqun MA
;
Ping CAI
- Publication Type:Journal Article
- Keywords:
Bone marrow stem cells;
Myocardial infarction;
Homing
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the time window of bone marrow stem cell homing to the inchemia myocardium. METHODS: 110 SD male rats were randomly divided into four groups: GM-CSF-treated group (n=40) and sham-treated group (n=15) were given GM-CSF (50 ?g/kg/d) for 5days. The control group (n=40) and its sham-treated group (n=15) was injected equal volume of saline, acute myocardiar infarction were induced by LAD ligation in each group. At 1, 3, 5, 10 days in each group, the homed bone marrow stem cells were detected by expression of c-kit with immunohistochemical methods. Cardiac performance and pathological changes were examined at 28 days. RESULTS: At 28 days, both systolic function and diastolic function in GM-CSF-treated group were significantly higher than those in control group (P
