Effects of platelet-derived growth factor on vasoconstriction of the vascular vessels in rats
- VernacularTitle:血小板衍生生长因子致大鼠血管的收缩作用
- Author:
Yusheng REN
;
Zonggui WU
;
Zuo HUANG
;
Xiaoming PAN
;
Rongzeng DU
;
Xingjian GU
- Publication Type:Journal Article
- Keywords:
Platelet-derived growth factor;
Aorta;
Vasoconstriction;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of platelet-derived growth factor BB (PDGF-BB) on vasoconstriction of the vascular vessels. METHODS: The contractile effects of PDGF-BB at different concentrations on the rat thoracic aortic rings and the effects of verapimil, indomerthacin, phentolamine and propranolol on the response of the thoracic aortic rings were observed by using the technique of vascular perfusion in vitro, and norepinephrine was used to severe as control. RESULTS: PDGF-BB showed a remarkable contractile effect on the thoracic aorta rings of rats in a dose-dependent manner, more potent than norepinephrine at the same molar concentration. Verapimil and propranolol inhibited the contractile effect of PDGF-BB on the rat thoracic rings, but the effect of indomerthacin and phentolamine on the vasoconstriction of PDGF-BB was not observed. CONCLUSION: PDGF-BB significantly contracts the thoracic aorta rings of rats in dose-dependent and non-endothelium-dependent manners. Verapimil and propranolol inhibits the contractile effect of PDGF-BB on the rat thoracic rings.
