Expression of MMP-9 and TIMP-1 and Its Correlation with Lymph Node Metastasis in Esophageal Squamous Carcinoma
- VernacularTitle:MMP-9和TIMP-1在食管鳞癌中的表达及其与淋巴结转移的关系
- Author:
Sihai GAO
;
Jinping ZHAO
;
Tiecheng PAN
- Publication Type:Journal Article
- Keywords:
Esophageal squamous carcinoma;
Matrix metalloproteinase;
Tissue inhibitor of metalloproteinase
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1), and its correlation with lymph node metastasis in esophageal squamous carcinoma(ESC). Methods The expressions of MMP-9 and TIMP-1 were detected in 78 cases of esophageal squamous carcinomas by using immunohistochemical SP method. Results The expression level of MMP-9 in high differentiated (grade Ⅰ～Ⅱ) and early stage (stageⅠ～Ⅱ) ESC was significantly lower than that in low differentiated(grade Ⅲ～Ⅳ) and late stage (stage Ⅲ～Ⅳ) ESC(P
