Effect of Pulmonary Artery Perfusion with Modified LPD Solution on Cardiopulmonary Bypass-induced Systemic Inflammatory Response
- VernacularTitle:改良LPD肺动脉灌注对体外循环术后全身炎症反应的影响
- Author:
Liming LIU
;
Jianguo HU
;
Bangliang YIN
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Pulmonary artery perfusion;
Systemic inflammatory response;
Cytokine
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of pulmonary artery perfusion with the modified low-potassium dextran(LPD) solution on cardiopulmonary bypass(CPB)-induced systemic inflammatory response. Methods 30 patients undergoing mitral valve replacement were randomly divided into control group (n=15) and lung perfusion group (n=15). The patients in the lung perfusion group were perfused with the modified LPD solution by pulmonary artery during CPB. The patients in the control group underwent the routine procedure of mitral valve replacement. The plasma concentrations of TNF-? and IL-8 were measured before and 0 h, 6 h after surgery by ABC-ELISA. Results The plasma levels of TNF-? and IL-8 significantly increased after surgery in both groups. The plasma levels of TNF-? and IL-8 were significantly lower(P
