Expression of TRAIL and TRAILR in human hepatocellular carcinoma and its therapeutic significance
- VernacularTitle:TRAIL和TRAILR在肝癌中表达及对肝癌的治疗作用
- Author:
Zhenyu XIAO
;
Xiaoping CHEN
;
Songqing HE
;
Zhiyong HUANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,heptocellular;
Tumor necrosis;
TRAIL;
TRAILR;
Cytotoxicity
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) and its receptor(TRAILR) in human hepatocellular carcinoma (HCC), and its therapeutic potential for human HCC. Methods Expressions of TRAIL and TRAILR were determined in and adjacent to carcinoma tissues, and normal liver tissues. The cytotoxic effects of TRAIL in combination with chemotherapeutic agents on HCC cell lines were detected. Results Expression of TRAIL in tumor adjacent tissue was higher than in cancer tissue. There were high expression of DR and low expression of DcR in HCC tissue in contrast to normal hepatic tissue(?~ 2=4.68,P
