Prognostic significance of MMP-2、MMP-9、Cathepsin-D expression in lymph node-negative breast carcinoma
- VernacularTitle:MMP-2、MMP-9、Cathepsin-D在淋巴结阴性乳腺癌中的表达及其与预后的关系
- Author:
Daocheng CAO
;
Yi LIU
;
Qiang HOU
;
Junkun ZHANG
;
Jie CUI
;
Hecheng LI
;
Zhimin SHAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Prognosis;
MMP-2;
MMP-9;
Cathepsin-D
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic significance of MMP-2 , MMP-9 and Cathepsin-D expression in lymph node-negative human breast carcinoma. Methods Specimens from the primary breast tumors of 270 axillary lymph node negative breast cancer patients were studied for MMP-2 , MMP-9 and Cathepsin-D protein expression by immunohistochemical staining. Results The positive expression of MMP-2, MMP-9 and Cathepsin-D was 56.7%(153/270),59.6%(161/270) and 55.6%(150/270), respectively. In univariate analysis, MMP-2, MMP-9 and the co-expression of MMP-2 and MMP-9 were significantly associated with tumor free survival. In multivariate analysis, co-expression of MMP-2 and MMP-9 was unfavorablely related with tumor free survival(RR=2.487; P
