Apolipoproteins as Differentiating and Predictive Markers for Assessing Clinical Outcomes in Patients with Small Cell Lung Cancer.
10.3349/ymj.2016.57.3.549
- Author:
Jian SHI
1
;
Huichai YANG
;
Xiaoyang DUAN
;
Lihua LI
;
Lulu SUN
;
Qian LI
;
Junjun ZHANG
Author Information
1. Department of Medical Oncology , Forth Hospital of Hebei Medical University, Tumor Hospital of Hebei Province, Shijiazhuang, Hebei, China. jianshihebei@gmail.com
- Publication Type:Original Article
- Keywords:
Small cell lung cancer;
apolipoprotein;
biomarker;
prognosis
- MeSH:
Adult;
Aged;
Apolipoprotein A-I/*genetics;
Apolipoprotein C-III/*genetics;
Apolipoproteins E/*genetics;
Biomarkers/analysis;
Case-Control Studies;
Female;
Gene Expression Regulation;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Predictive Value of Tests;
Prognosis;
RNA, Messenger/*genetics;
Small Cell Lung Carcinoma/*diagnosis/genetics
- From:Yonsei Medical Journal
2016;57(3):549-556
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The present study aimed to investigate the value of apolipoproteins, including ApoA-1, ApoC-III, and ApoE, in patients with small cell lung cancer (SCLC) as potential biomarkers for diagnosis, prognosis, and cancer progression. MATERIALS AND METHODS: Lung samples were collected from 89 patients with SCLC. Nineteen lung samples from non-small cell lung cancer (NSCLC) patients and 12 normal lung tissues were used as controls. Expression profiles of ApoA-1, ApoC-III, and ApoE in different samples were examined using immunohistochemical methods, and the expression levels were correlated with cancer types, treatment, and outcomes using chi-square and Mann-Whitney tests. RESULTS: Expression of ApoA-1 and ApoC-III in SCLC was significantly different, compared with that in NSCLC and normal lung tissues, and was correlated with recurrence of SCLC. Patients undergoing neoadjuvant chemotherapy before surgery showed significantly reduced expression of ApoA-1 and increased expression of ApoC-III and ApoE. Nevertheless, the expression levels of ApoA-1, ApoC-III, and ApoE were not correlated with SCLC staging. CONCLUSION: ApoA-1 and ApoC-III may be used as differentiating and predictive markers for SCLC. ApoA-1, ApoC-III, and ApoE may be used to monitor the efficacy of chemotherapy.
