Formulation Optimization and Stability Study of Acitretin Capsule
- VernacularTitle:阿维A胶囊处方筛选及稳定性研究
- Author:
Kui LIU
- Publication Type:Journal Article
- Keywords:
Acitretin capsule;
Optimization of formulation;
Dissolution;
Stability
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the best formulation and process of acitretin capsule and to study the stability of its finished preparation.METHODS:The orthogonal experiment was conducted with the formula quantity of amylum pregela?tinisatum,lactose and low-substituted hydroxypropyl cellulose(L-HPC)as the determination factors,the comprehensive e?valuation was conducted with dissolution rate,flowability,content uniformity and so on as the quality determination index of finished preparation;The stability of the finished preparation was determined under illumination,high temperature and high-moisture.RESULTS:The best formulation was composed of the following,amylum pregelatinisatum20%,lactose20%,L-HPC1%,which was prepared by granulating process;The finished preparation was stable in quality.CONCLUSION:The optimized formulation and technics of acitretin capsule were reasonable and the dissolution,content uniformity and stability of the finished preparation from which were in conformity with China Pharmacopoeia.
