Study on the Pharmaceutical Effect of Surfactants on the Sucralfate Capsule
- VernacularTitle:表面活性剂对硫糖铝胶囊药剂学的影响研究
- Author:
Qin WANG
- Publication Type:Journal Article
- Keywords:
Sucralfate;
Capsule;
Surfactants;
Sodium lauryl sulphate
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of surfactants on the pharmaceutical index of sucralfate capsule and to opti?mize its dosage used in the formula.METHODS:The sucralfate capsule was prepared with different surfactants respectively.The disintegration,dissolution and dispersibility of the preparations were determined and their stripping curves were fitted with Weibull distribution model.Different surfactants and the effects of different dosages of which on the dissolution of su?cralfates were compared.RESULT:The sodium lauryl sulphate had the biggest promotion effect on the dissolution of sucral?fate.Optimal indexes of the capsule were achieved when the addition of sodium lauryl sulphate was2%.CONCLUSION:It is advisable to adopt2%sodium lauryl sulphate as the surfactants for the sucralfate capsule.
