Clinical Significance of CA125 Level after the First Cycle of Chemotherapy on Survival of Patients with Advanced Ovarian Cancer.
10.3349/ymj.2016.57.3.580
- Author:
Maria LEE
1
;
Min Young CHANG
;
Hanna YOO
;
Kyung Eun LEE
;
Doo Byung CHAY
;
Hanbyoul CHO
;
Sunghoon KIM
;
Young Tae KIM
;
Jae Hoon KIM
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
CA125;
ovarian cancer;
prognostic factor;
tumour marker
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Antineoplastic Agents/*therapeutic use;
CA-125 Antigen/*blood/metabolism;
Disease-Free Survival;
Female;
Humans;
Middle Aged;
Neoplasm Staging;
Neoplasms, Glandular and Epithelial/*blood/*drug therapy/mortality;
Ovarian Neoplasms/*blood/*drug therapy/mortality;
Prognosis;
Regression Analysis
- From:Yonsei Medical Journal
2016;57(3):580-587
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To determine the most powerful cancer antigen 125 (CA125)-related prognostic factor for advanced epithelial ovarian cancer (EOC) and to identify cut-off values that distinguish patients with a poor prognosis from those with a good prognosis. MATERIALS AND METHODS: We included 223 patients who received staging laparotomy and were diagnosed with stage IIC-IV serous EOC. Cox regression analysis was used to determine the most significant prognostic factor among the following variables: serum CA125 before surgery and after the first, second, and sixth cycles of chemotherapy; the nadir CA125 value; the relative percentage change in CA125 levels after the first and second cycles of chemotherapy compared to baseline CA125; CA125 half-life; time to nadir; and time to normalization of the CA125 level. RESULTS: The CA125 level after the first chemotherapy cycle was the most significant independent prognostic factor for overall survival (OS). Time to normalization (p=0.028) and relative percentage change between CA125 levels at baseline and after the first chemotherapy cycle (p=0.021) were additional independent prognostic factors in terms of OS. The CA125 level after the first chemotherapy cycle (p=0.001) and time to normalization (p<0.001) were identified as independent prognostic factors for progression free survival (PFS). CONCLUSION: Among well-established CA125-related prognostic factors, serum CA125 levels after the first cycle of chemotherapy and time to normalization were the most significant prognostic factors for both OS and PFS.
