Study on the Bioequiavailability of Diclofenac Potassium Capsule in Human Body
- VernacularTitle:双氯芬酸钾胶囊的人体生物等效性研究
- Author:
Jie PAN
- Publication Type:Journal Article
- Keywords:
Diclofenac potassium capsule;
Bioavailability;
HPLC-MS
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the bioequiavailability of2kinds of diclofenac potassium capsules in human body.METHODS:The blood concentrations of the20healthy male volunteers were determined by HPLC-MS;the pharmacokinetics and the bioequiavailability in whom were calculated after orally taking by randomized crossover way single dose of trial capsule and reference capsule.RESULT:The concentration-time curves of the trial capsules and the reference capsules were in conformity with one-compartment model.The experiment data showed that the AUC 0～8 of the2kind of capsules were(2.27?0.66)、(2.16?0.58)(?g?h)/ml,respectively;their C max were(1.27?0.40)and(1.38?0.58)?g/ml,respectively;their t max were(0.9?0.7)、(1.0?0.7)h,respectively.The relative bioavailability of the trial capsules was(104.9?12.8)%.CONCLUSION:The2kinds of diclofenac potassium capsules are bioequivalent.
