Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography.
10.3349/ymj.2016.57.3.599
- Author:
Yoon Jin CHA
1
;
Ji Hyun YOUK
;
Baek Gil KIM
;
Woo Hee JUNG
;
Nam Hoon CHO
Author Information
1. Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. cho1988@yuhs.ac
- Publication Type:Evaluation Studies ; Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Breast neoplasms;
lymphangiogenesis;
fibrosis;
elasticity imaging techniques
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Breast/pathology;
Breast Neoplasms/*diagnostic imaging/*pathology;
Elasticity Imaging Techniques/*methods;
Female;
Humans;
Lymph Nodes/pathology;
Lymphangiogenesis/*physiology;
Lymphatic Metastasis/*pathology;
Middle Aged;
Multivariate Analysis;
Neoplasm Invasiveness;
Neoplasm Staging;
Regression Analysis
- From:Yonsei Medical Journal
2016;57(3):599-605
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. MATERIALS AND METHODS: A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed. RESULTS: Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value. CONCLUSION: In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.
