Serial Morphological Changes of Side-Branch Ostium after Paclitaxel-Coated Balloon Treatment of De Novo Coronary Lesions of Main Vessels.
10.3349/ymj.2016.57.3.606
- Author:
Ae Young HER
1
;
Soe Hee ANN
;
Gillian Balbir SINGH
;
Yong Hoon KIM
;
Takayuki OKAMURA
;
Scot GARG
;
Bon Kwon KOO
;
Eun Seok SHIN
Author Information
1. Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
- Publication Type:Observational Study ; Original Article
- Keywords:
Paclitaxel-coated balloon;
de novo coronary lesion;
main vessel;
side-branch ostium;
optical coherence tomography
- MeSH:
Aged;
Angioplasty, Balloon, Coronary/*methods;
Coronary Angiography;
Coronary Stenosis/diagnosis/*therapy;
Coronary Vessels/*pathology;
*Drug-Eluting Stents/adverse effects;
Female;
Humans;
Male;
Middle Aged;
Paclitaxel/*administration & dosage;
Prospective Studies;
Tomography, Optical Coherence/*methods;
Treatment Outcome;
Tubulin Modulators/administration & dosage
- From:Yonsei Medical Journal
2016;57(3):606-613
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The effects on the side-branch (SB) ostium, following paclitaxel-coated balloon (PCB) treatment of de novo coronary lesions of main vessels have not been previously investigated. This study was aimed at evaluating the serial morphological changes of the SB ostium after PCB treatment of de novo coronary lesions of main vessels using optical coherence tomography (OCT). MATERIALS AND METHODS: This prospective, single-center observational study enrolled patients with de novo lesions, which were traversed by at least one SB (≥1.5 mm) and were treated with PCB. The SB ostium was evaluated with serial angiographic and OCT assessments pre- and post-procedure, and at 9-months follow-up. RESULTS: Sixteen main vessel lesions were successfully treated with PCB, and 26 SBs were included for analysis. Mean SB ostial lumen area increased at 9-months follow-up (0.92±0.68 mm2 pre-procedure, 1.03±0.77 mm2 post-procedure and 1.42±1.18 mm2 at 9-months). The SB ostial lumen area gain was 0.02±0.24 mm2 between pre- and post-procedure, 0.37±0.64 mm2 between post-procedure and 9-months, and 0.60±0.93 mm2 between pre-procedure and 9-months. The ostial lumen area increased by 3.9% [interquartile range (IQR) of -33.3 to 10.4%] between pre- and post-procedure, 52.1% (IQR of -0.7 to 77.3%) between post-procedure and 9-months and 76.1% (IQR of 18.2 to 86.6%) between pre-procedure and 9-months. CONCLUSION: PCB treatment of de novo coronary lesions of main vessels resulted in an increase in the SB ostial lumen area at 9-months.
