Polymorphic expression of UDP-glucuronosyltransferase UGT1A gene locus in human colorectal epithelium
- VernacularTitle:结直肠癌患者肠道UGT1A基因的多态性表达
- Author:
Min WANG
;
Yanqing LI
;
Defeng SUN
;
Zhimin WANG
;
Xiaoqun XU
;
Mengbiao YUAN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Glucuronosyltransferase;
Genes, UGT1A;
Polymorphism (genetics)
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To analyze the polymorphic expression of UDP-glucuronosyltransferase UGT1A gene locus in human colorectal epithelium. METHODS: Colorectal tissue samples were obtained from 40 patients with colorectal cancer and 20 normal controls. The levels of UGT1A transcriptions were detected by RT-PCR, exon-1 specific RT-PCR. UGT1A proteins were measured by Western blotting analysis. RESULTS: (1) UGT1A mRNA expression was found to be significantly down-regulated in colorectal cancer tissue as compared with the surrounding healthy tissues (P
