Effect of zinc on sister chromatid exchange induced by cadmium in human lymphocytes
- VernacularTitle:锌对镉诱导人淋巴细胞姊妹染色单体交换的影响
- Author:
Chipeng WU
;
Xueyun ZHONG
;
Shengyong WANG
;
Chunxia JING
;
Cunxin FAN
- Publication Type:Journal Article
- Keywords:
Cadmium;
Zinc;
Chromosome;
Mutation
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the mutagenicity of cadmium and zinc and the effect of zinc on the mutagenicity of cadmium. METHODS: The frequency of sister chromatid exchange (SCE) induced by cadmium, zinc and the combination of cadmium and zinc were observed in cultured human lymphocytes. RESULTS: Cadmium induced the increase in frequency of SCE in human lymphocytes from the concentration 1?10~(-8) mol/L to 1?10~(-6) mol/L, but zinc had a negative result. Zinc reduced the frequency of SCE induced by cadmium at the concentration from 1?10~(-6) mol/L to 1?10~(-4) mol/L and a relationship between dose and effect was also observed. CONCLUSION: Zinc inhibits the mutagenicity of cadmium in cultured human lymphocytes.
