Relationship between subclasses of serum HDL and LPL gene HindⅢ polymorphism in hyperlipidemia
- VernacularTitle:高脂血症患者HDL亚类组成与脂蛋白酯酶基因内含子8 HindⅢ多态性的关系
- Author:
Ying TIAN
;
Rong ZHANG
;
Shiyin LONG
;
Mingde FU
;
Yanhua XU
- Publication Type:Journal Article
- Keywords:
Hyperlipidemia;
Lipoprotein lipase;
HDL subclasses
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate lipoprotein lipase gene HindⅢ polymorphism and its relationship with serum lipids and apolipoprotein, serum HDL subclasses in patients with hyperlipoidemia. METHODS: Lipoprotein lipase gene HindⅢ polymorphism was assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The subclasses of serum HDL in 152 hyperlipoidemia patients and 128 healthy subjects were determined by two-dimensional gel electrophoresis conjunction with immunodetection method. RESULTS: H+H+ genotype and allele H+ in hyperlipoidemia and control groups were both the highest. In hyperlipidemia group, H+H+ genotypes tended to be higher than that in control group, while H+H- and H-H- genotypes were significantly lower (P
