Expression of TNF-? and TGF-? in oral lichen planus patients
- VernacularTitle:口腔扁平苔癣固有层TNF-?、TGF-?的表达及其临床意义
- Author:
Lei LEI
;
Haiwei ZHANG
;
Zhenzhen ZHONG
;
Bin DU
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor;
Transforming growth factor beta;
Lichen planus, oral
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of TNF-?, TGF-? in patients with oral lichen planus (OLP) and normal oral mucosa (NOM). METHODS: An immunohistochemical technique was performed to detect TNF-?, TGF-?_1 and TGF-?_2 expression in 22 cases with OLP and 10 normal controls. RESULTS: In lamina propria of OLP, the expression of TNF-? and TGF-?_1 were increased, whereas TGF-?_2 did changed significantly compared with control group. TNF-? positive signal were mostly found in macrophages, lymphocytes. TGF-?_1 positive cell was present in macrophages, endothelial cells and fibrocytes. CONCLUSION: TNF-? and TGF-?_1 play an important role in the development and maintenance of OLP local inflammation.
