Role of mitogen-activated protein kinase in myocardial hypertrophy
- VernacularTitle:丝裂原活化蛋白激酶信号途径在心肌肥厚中的作用进展
- Author:
Zhaoyang HUANG
;
Jianhua ZHU
- Publication Type:Journal Article
- Keywords:
Mitogen-activated protein kinases;
Myocardium;
Hypertrophy;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial hypertrophy is an independent risk factor for cardiac events. Mitogen-activated protein kinases (MAPK), including extracellular signal-regulated kinases, C-jun N-terminal kinases and P38-MAPK, are the common intracellular pathway of transducing hypertrophic signs. All three MAPK subfamilies play an important role in development of myocardial hypertrophy.
