Preparation of Levofloxacin Thermosensitive Ocular Gel and Study on Drug Release in Vitro
- VernacularTitle:左氧氟沙星热敏型眼用凝胶的研制及体外释放研究
- Author:
Fei GAO
;
Dongkai WANG
;
Songlin XU
;
Lai LIU
- Publication Type:Journal Article
- Keywords:
Levofloxacin;
Poloxamer407;
Thermosensitive gel for ophthalmic drug delivery;
Drug release in vitro;
Membraneless dissolution model
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare the levofloxacin(LEF)thermosensitive gel for ophthalmic drug delivery,and to study the drug release in vitro.METHODS:Poloxamer407was used as themosensitive material for the LEF eye drop,the best con?centration of poloxamer in prescription was selected according to the temperature of gel,a novel membraneless model was used to study the drug release.RESUTS:The detected concentration of LEF was in the linear range of3～11?g/ml(r=0.9991,n=6),the recovery was99.62%;The best concentration of poloxamer in prescription was18%;Drug release followed zero-order kinetics,and the quantity of drug release was controlled by that of gel dissolution.CONCLUSION:The preparation is simple in method and easy to control in dosage,therefore it shows a promising future in development.
