Efficacy of Calcium Dobesilate on Glomerular Basement Membrane in Diabetic Rats
- VernacularTitle:羟苯磺酸钙对糖尿病模型大鼠肾小球基底膜的影响研究
- Author:
Junwu DONG
;
Xiaocheng LIU
;
Shenwei LIU
;
Mingbo LI
;
Yanmei XU
;
Bing CUI
- Publication Type:Journal Article
- Keywords:
Calcium dobesilate;
Diabetes mellitus;
Ultrastructure;
Basement membrane
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of calcium dobesilate on the ultrastructure of glomerular basement membrane(GBM)in diabetic rats.METHODS:30rats underwent unilateral nephrectomy,of whom,10were assigned to the normal control group(group NC),another20were induced to diabetic models(DM)by intraperitoneal injection of1%STZ,the models which have finished were divided into DM control group and calcium dobesilate group(group DD),each group admin?istered with distilled water and calcium dobesilate respectively,12weeks later,the change in the ultrastructure of kidneys and endogenous creatinine clearance rate(CrCl)in each group were observed.RESULTS:After12weeks,endogenous CrCl in group DD was significantly higher than that in group DM;Electron microscope showed that thickening of glomerular capillary basement membrane in group DD was less than that in group DM.CONCLUSION:Calcium dobesilate could improve the ul?trastructure in kidney of diabetic rats,prevent GBM thickening,and protect filtration barrier of renal glomerulus.
