The protective effects of lldocaine on the brain against injury induced by microsphere embolism in rats
- VernacularTitle:利多卡因对大鼠微栓栓塞致脑损伤的保护作用
- Author:
Zhen HUA
;
Dongxin WANG
;
Xinmin WU
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Briain injuries;
Intracranial embolism and thrombosis
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate if lidocaine can alleviate the behavioral disorder, learning and memory dysfunction and neuropathological lesions induced by cerebral microsphere embolism. Methods Sixty-five healthy male Wistar rats weighing 210-270 g were randomly divided into 5 groups: 2 microsphere groups (n= 14 each) , 2 lidocaine pretreatment groups (n=12, 13) and control group (n= 8) . The animals were anesthetized with isoflurane, 60% nitrous oxide and O2 . In the microsphere groups 600 or 900 microspheres were injected into right internal carotid artery. In the lidocaine pretreatment groups a bolus of lidocaine 1.5 mg?kg-1 was given via femoral vein 30 min before microsphere injection followed by lidocaine infusion at 2 mg?kg-1?h-1 until 1h after microsphere injection. In control group vehicle without microsphere was injected. The behavior score was recorded every day from the 1st to 7th day after microsphere injection. The Morris water maze test was performed 3 times a day starting from the 8th to 12th day after microsphere injection. The animals were sacrificed after the last water maze test. Brains were removed for microscopic examination of the hippocampus CA1 region.Results (1) The behavioral scores (0 = no typical signs, 9 = worst results) decreased with time after embolism in all groups and were significantly higher in the microsphere and lidocaine groups than in control group. They were significantly higher in microsphere group 2 than in microsphere group 1 and the two lidocaine groups (P
