Experimental study on percutaneous selective isolated hepatic perfusion chemotherapy
- VernacularTitle:经皮选择性肝脏隔离灌注化疗的实验研究
- Author:
Jinsong HE
;
Chengyou WANG
;
Xianming WANG
;
Liangfeng GUO
;
Haohui LIANG
;
Yongqiang ZHAN
;
Ruming ZHOU
;
Shuibo QIU
;
Wenjing QIAN
;
Jisheng CHEN
- Publication Type:Journal Article
- Keywords:
Liver Neoplasms,Experimental/durg ther;
Perfusion,Rejional;
Fluorouracil/ther use
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the feasibility and isolation efficiency of percutaneous selective isolated hepatic perfusion chemotherapy(PSIHP). MethodsSix pigs underwent the procedure of routine transhepatic arterial infusion(HAI) and 6 underwent PSIHP.5-FU was used in this study. The drug(5-FU) (concentration) of blood from hepatic and systemic veins of both groups was observed. Liver tissue was (investigated) for pathologic changes. ResultsThe peak level of 5-FU concentration in blood from right (hepatic) vein and systemic vein in HAI group was(4082.530415.213)mg/L and (1682.230216.834)mg/L respectively.In PSIHP group, the peak level(5-FU) was(5321.711517.318)mg/L and(510.83452.518)mg/L, respectively.There was a statistically significant difference between HAI group an PSIHP group(P
