Simultaneous kidney-pancreatic transplantation with portal venous and enteric drainage:a report of 6 cases
- VernacularTitle:经门静脉及肠道引流式一期胰肾联合移植六例报告
- Author:
Lin ZHONG
;
Zhihai PENG
;
Zhengjun QIU
;
Qiang XIA
;
Guoqing CHEN
;
Zhecheng ZHU
;
Junming XU
;
Jun LIU
;
Shuyun WANG
- Publication Type:Journal Article
- Keywords:
Pancreas transplantation;
Kidney transplantation;
Diabetes mellitus, insulin-dependent;
Drainage
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical effect of simultaneous kidney-pancreatic transplantation(SKPT) with portal venous and enteric drainage. Method Between June 2001 and June 2004, six insulin-dependent diabetes mellitus(IDDM) and renal failure patients underwent this procedure. The venous drainage of the graft was established between donor′s portal vein and recipient′s superior mesenteric vein. The exocrine secretion was drained into proximal jejunum via side-to-side anastomosis between donor′s duodenum and recipient′s proximal jejunum. Steroids, mycophenolate mofetil, tacrolimus and Zenapax were used as immunosuppressants. Results Procedures were successful in all 6 cases. Excellent renal function and euglycemia were achieved in 4 cases. Follow-up of 4-34 months on the 4 survivers found excellent kidney-pancreatic function without any rejection episode. Two patients died perioperatively due to sepsis secondary to pancreatic leakage and drug toxicosis of excessive FK506. Conclusion Our preliminary experience suggests that simultaneous pancreas-kidney transplantation with enteric and portal drainage is reliable procedure for the treatment of IDDM with renal failure.
