Clinicopathologic and prognostic significance of thymidine phosphorylase and dihydropyrimidine dehydrogenase activity in human colorectal carcinoma
- VernacularTitle:人结直肠癌组织中胸腺嘧啶核苷磷酸化酶和二氢嘧啶脱氢酶的活性变化及其意义
- Author:
Mujun YIN
;
Shan WANG
;
Yingjiang YE
;
Kewei JIANG
;
Zhirong CUI
;
Bin LIANG
;
Weigang FANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Thymidine phosphorylase;
Dihydropyrimidine dehydrogenase;
5-flouorouracil
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was to investigate the relationship between the activities of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) and clinicopathological parameters in human colorectal cancer,and the relationship between TP and/or DPD activity in tumor tissue and efficiency of chemotherapy. MethodsSixty-eight patients undergoing surgery for primary colorectal cancer were enrolled including 40 patients receiving postoperative adjuvant chemotherapy with 5-FU plus leucovorin(de Gramont regimen). The activities of TP and DPD both in tumor tissue and in normal tissue were determined by enzyme-linked immunosorbent assay(ELISA). Results The TP activity was significantly higher in tumor than in normal tissues(P
