Eicosanoid metabolic disturbance and the role of calcium channel bocker in murine acute pancreatitis
- VernacularTitle:大鼠急性胰腺炎时花生四烯酸代谢紊乱及钙拮抗剂的治疗作用
- Author:
Xinze ZHOU
;
Qinshen MAO
;
Yiaohui NI
;
Xiu YU
;
Ruixin CHEN
;
Liping LU
;
Yuquan CHEN
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Arachidonic acids;
Calcium channel blockers
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the alterations of thromboxane (TXB_2)、 prostacyclin (PGI_2)in murine acute pancreatitis (AP) and the therapeutic effect of calcium channel bocker-verapamil. MethodsA rat AP model was established to observe the alterations of plasma levels of TXB_2, 6-keto-PGF_ 1? and TXB_2/6-keto-PGF_ 1? ratio and the effect of verapamil. Pancreatic histology was examined by light and electron microscopy. ResultsAt 16 and 24 hours after induction of AP, the plasma levels of TXB_2[(1112?235)pg/ml、(1265?162)pg/ml] and TXB_2/6-keto-PGF_ 1? ratio(9.9?0.9,10.2?1.3)increased significantly. With varapamil therapy, the plasma levels of TXB_2[(671?102)pg/ml、(697?93)pg/ml] and TXB_2/6-keto-PGF_ 1? ratio (6.9?2.2)、(6.4?0.7) were dramatically lower than those in control group (P
