Effects of D-limonene on lymphangiogenesis and lymph node metastasis in implanted breast cancer model
- VernacularTitle:右旋柠烯对乳腺癌淋巴管生成和淋巴结转移影响的实验研究
- Author:
Qing LU
;
Mingyang QU
;
Guangming XING
;
Zhihong YU
;
Guiping ZHANG
;
Bingan FENG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Neoplasm metastasis;
D-limonene;
Lymphangiogenesis;
Endothelial growth factor
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of D-limonene on lymphangiogenesis and lymph node metastasis in breast cancer. Methods Human breast cancer cell lines MDA-MB-435 were implanted into the mammary fat pad of 24 female nude mice to establish breast cancer model. The tumor volume and the incidences of lymph node metastasis were detected. Immunohistochemical staining was used to detect the lymphatic microvessel density and VEGF-C expression of the breast cancer tissues. Results In D-limonene group, tumor volume(0.824?0.31) and incidences of lymph node metastasis(25.0%) were significantly inhibited compared with control group (2.178?0.35,87.5%)(all P
