Effect of intravitreous injection with triamcinolone acetonide on retina
- VernacularTitle:曲安奈德玻璃体内注射对视网膜的影响
- Author:
Kai WANG
;
Yanrong JIANG
;
Xiaoxin LI
- Publication Type:Journal Article
- Keywords:
Tiamcinolone acetonide/therapeutic use;
Tiamcinolone acetonide/toxicity;
Retina/drug effects
- From:
Chinese Journal of Ocular Fundus Diseases
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of triamcinolone acetonide (TA) with different dosage and excipient on retina. Methods Thirty-two purebred New Zealand white rabbits randomly divided into 4 groups underwent intravitreous injection with TA. Group 1:4 mg TA without excipient; group 2:25 mg TA without excipient; group 3:4 mg TA with excipient; group 4:25 mg TA with excipient. Electroretinography (ERG) was performed on each rabbit before intravitreal injection, 1 week, 1 and 2 months after the injection. All the animals were killed and the eyeballs were extirpated 2 months after the injection, and pathological examinations including light and electron microscopy were performed. Results No significant difference was found in the latent period of ERG at the points of time before and after the injection in all the groups, but the amplitudes of ERG waves was lower in groups containing excipient than that before the treatment (P
