Expression and significance of NgR mRNA in adult rats′ optic nerve
- VernacularTitle:Nogo-66受体mRNA在成年大鼠视神经中的表达及意义
- Author:
Chunlin CHEN
;
Jian YE
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Optic nerve/immunology;
Sciatic nerve/immunology;
Nerve regeneration;
Gene expression
- From:
Chinese Journal of Ocular Fundus Diseases
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and evaluate the expression and significance of Nogo-66 receptor (NgR) mRNA in adult rats′ optic nerve. Methods Optic and sciatic nerves of 8 adult rats were used to make the sections, which were divided into 3 groups: optic-nerve experimental group, sciatic-nerve control group, and optic-nerve negative control group. In situ hybridization was used to observe the expression of NgR mRNA in optic nerve and sciatic nerve. Results The expression of NgR mRNA in the 8 rats was positive in optic nerve and negative in sciatic nerve. The positive signals were arranged along the long axis of optic nerve. Conclusion The expression of NgR mRNA is positive in optic nerve while negative in sciatic nerve in adult rats, which suggests that the positive expression and distribution of NgR may be related to the poor regenerate ability of optic nerves.
