The Role of Pituitary Tumor Transforming Gene in the Pathogenesis of Pituitary Adenomas
- VernacularTitle:垂体肿瘤转化基因对垂体腺瘤发生和发展作用机制的研究
- Author:
Chun XU
;
Yali LIU
- Publication Type:Journal Article
- Keywords:
Pituitary tumor transforming gene;
Rat;
Pituitary adenoma;
RT-PCR
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of pituitary tumor transforming gene (PTTG) in estrogen-induced rat prolactinoma and various types of human pituitary adenomas to explore the role of PTTG in pituitary tumor oncogenesis. Methods Rat model of estrogen-induced prolactinoma was set up, and PTTG mRNA level in rat prolactinoma was measured by RT-PCR. The expression levels of PTTG and bFGF mRNA in 32 cases of human pituitary adenomas were measured by RT-PCR as well. Results The expression level of PTTG mRNA in rat prolactinoma was obviously higher than that in control pituitary tissue(P
