The Association of Anti-C1q Antibody with Disease Activity and Lupus Nephritis in Patients with SLE
- VernacularTitle:抗C1q抗体检测与SLE疾病活动性及狼疮性肾炎关系探讨
- Author:
Ming GAO
;
Aiguo TAN
;
Aihua LIU
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Lupus nephritis;
Anti-C1q antibody;
Anti-dsDNA antibody;
Complement
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of anti-C1q antibody with disease activity and lupus nephritis in patients with systemic lupus erythematosus(SLE). Methods The serum Level of anti-C1q antibody was determined in 35 patients with SLE by ELISA. The correlation between anti-C1q level and other disease activity parameters, such as SLEDAI score, anti-dsDNA antibody, C3, C4 and CH50 levels, was analyzed. Results Anti-C1q antibody was positive in 51.4% of patients with SLE, the positive rates in patients with active nephritis and without one was 77.8%(14/18) and 42.3%(22/52), respectively, and that was significantly higher in the former than in the later(P
