Expression of MT and p53 in Non-small Cell Lung Carcinoma
- VernacularTitle:非小细胞肺癌中MT蛋白与P53表达的研究
- Author:
Xinhua LV
;
Lang XU
;
Jianhui YAN
- Publication Type:Journal Article
- Keywords:
Carcinoma;
NSCLC;
Pathology;
Metallothionein;
Immunohistochemistry
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Investigate the expression of metallothionein (MT) and p53 in non-small cell lung carcinoma(NSCLC). Methods The expression of MT and p53 was detected by immunohistochemical method in the paraffin-embedded specimens of 73 NSCLCs and 15 normal bronchial mucosal tissues(NBMT). Results [WTBZ]The positive rates of MT and p53 expression in NSCLC were 54.8%(40/73)and 65.8%(48/73), respectively, and in NBMT were 20.0%(3/15)and 33.3%(5/15), respectively. The positive rates of both MT and p53 in NSCLC were significantly higher than those in NBMT(P0.05). The positive rates of MT and p53 were closely correlated with the histological grades and lymph node metastasis of NSCLC(P
