Study on the Effects of Arsenic Trioxide on the Encoding Protein Expressions of Metastatic Gene in Gastric Cancer Cells of Human Body
- VernacularTitle:三氧化二砷对人胃癌细胞株转移基因编码蛋白表达影响的研究
- Author:
Shumei LIU
;
Wei XU
;
Xiangyu MENG
;
Tao LIANG
;
Xin MENG
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Gastric cancer cells of human body;
Gene expression
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of arsenic trioxide(As 2 O 3 )on the encoding protein expressions of nm23and P53in gastric cancer cells and to study the anti-canecer mechanism of which in the tumor.METHODS:A control group and a test group were set up.The expressions of gene coding proteinum nm23and P53of the gastric cancer cells cultured in vitro by the action of As 2 O 3 were determined by immunohistochemistry method.RESULTS:The expression levels of nm23and P53in gastric cancer cells have been lowered compared with the control group.CONCLUSION:As 2 O 3 can exert its anti-tumor effect by decreasing the expression of gene coding proteinum of nm23and P53.
