Simultaneous Determination of 3 Components in Compound Paracetamol Tablets by HPLC
- VernacularTitle:高效液相色谱法同时测定复方对乙酰氨基酚片中3组分的含量
- Author:
Xiumei LI
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
HPLC;
Compound paracetamol tablets;
Paracetamol;
Caffeine;
Aspirin;
Content determination
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a HPLC method for the determination of paracetamol,caffeine and aspirin in compound paracetamol tablets.METHODS:The chromatographic column was ODS,the mobile phase was methanol-4.2% glacial acetic acid solution(3∶7)with a flow rate at1.0ml/min;the detecting wavelength was 275nm,the sample size was 20?l and the column temperature was 25℃.RESULTS:The linear ranges of paracetamol,caffeine and aspirin were 16.08～428.80?g/ml(r=0.9981),3.42～91.20?g/ml(r=0.9988) and 23.87～769.92?g/ml(r=0.9999) respectively;The average recovery were 99.2%(RSD=0.23%),100.4%(RSD=0.63%)and 99.3%(RSD=0.11%)respectively.CONCLUSION:This method was simple,fast and accurate,which can be used for the content determination of compound paracetamol tablets.
