Efficacy and Safety of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Adults
- VernacularTitle:他克莫司软膏治疗成人特应性皮炎疗效和安全性研究
- Author:
Lingling LIU
;
Xia DOU
;
Weijing WEN
;
Zhizhong ZHENG
;
Baoxi WANG
;
Lin LIN
;
Fanqin ZENG
;
Jun GU
;
Xuejun ZHU
- Publication Type:Journal Article
- Keywords:
Dermatitis, atopic;
Tacrolimus;
Randomized controlled trials
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of 0.1% and 0.03% tacrolimus ointment in patients aged 18 to 65 years with atopic dermatitis (AD). Methods Treatment was given twice daily to all affected areas for 3 weeks in a multicentre, randomized, double blind, parallel, and vehicle-controlled study. Follow-up visits were scheduled on day 1(baseline), and 1, 2 and 3 weeks post-treatment. The therapeutic effect and safety were evaluated. Results A total of 211 adults with moderate to severe AD in 6 study centres were enrolled in the efficacy evaluation. The efficacy rates were 88.4%, 77.8% and 30.0% in patients treated with 0.1%, 0.03% tacrolimus ointment, and the vehicle, respectively (P
