Benign Acanthosis Nigricans in Obese Children: An Indicator for High Risk of Diabetes
- VernacularTitle:假性黑棘皮病肥胖儿童:2型糖尿病的高危人群
- Author:
Junfen FU
;
Li LIANG
;
Guanping DONG
;
Xiumin WANG
;
Min ZHENG
- Publication Type:Journal Article
- Keywords:
Child;
Acanthosis nigricans;
Insulin resistance;
Diabetes mellitus, non-insulin-dependent
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between obese children with benign acanthosis ni-gricans and insulin-resistant and type 2 diabetes mellitus. Methods Levels of glucose, insulin, and glucose/ insulin ratio were measured on fasting blood specimens, and anthropometric parameters including waist/hip ratio, fat mass, body fat percentage and body mass index were examined in 42 obese children with benign acanthosis nigricans, 60 cases of simple obesity and 20 healthy children controls. Glucose tolerance tests were performed in groups of obese children with benign acanthosis nigricans and simple obesity, respectively. Results Two of 42 obese children with benign acanthosis nigricans were diagnosed as type 2 diabetes mellitus. The rate of abnormal glucose tolerance and levels of blood sugar during 60 min and 120 min after glucose tolerance were significantly higher in acanthosis nigricans children than those in simple obesity (P
