Changes of calcium handling protein after acute myocardial infarction in rats and effect of carvedilol
- VernacularTitle:急性心肌梗死大鼠钙调蛋白的改变及卡维地洛的干预作用
- Author:
Yilan SUN
;
Shenjiang HU
;
Lihong WANG
;
Jianying ZHOU
- Publication Type:Journal Article
- Keywords:
Heart failure, congestive;
Carvedilol;
Sarcoplasmic reticulum;
Ca~(2+)-transporting ATPase;
Phospholamban
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the changes of sarcoplasmic reticulum Ca~(2+)-ATPase (SERCA), phospholamban (PLB) during heart failure after acute myocardial infarction (AMI) in rats and the effect of carvedilol. METHODS: Rats were randomly assigned to normal control group, sham-operation group, AMI group and carvedilol (CAR) group. 6 weeks later, in vivo hemodynamic, morphometry and SERCA, PLB mRNA and protein expression of myocytes were measured in all animals. RESULTS: In comparison with sham-operation group, LV end diastolic pressure (LVEDP) and weight of ventricles were increased, while maximal rate of rise and fall (?dp/dt) of LV pressure were decreased in AMI group. After treatment with carvedilol, these parameters were all improved. The mRNA and protein expression of SERCA were downregulated (P0.05). CONCLUSIONS: The changes of SERCA and PLB may be the important mechanism of contractile dysfunction in heart failure after AMI. Carvedilol is effective in preventing LV dysfunction after AMI. The molecular mechanism may be related with normalization of SERCA expression.
