Effect of L-arginine on arrhythmia induced by ischemia/reperfusion of right coronary artery in rabbits
- VernacularTitle:L-精氨酸对兔右冠状动脉缺血再灌注所致心律失常的影响
- Author:
Qingzhi WANG
;
Xiaoqian ZHU
;
Yan LI
;
Haozhuang YANG
;
Lin YUAN
- Publication Type:Journal Article
- Keywords:
Ischemia;
Reperfusion;
Arrhythmia;
Arginine;
Coronary vessels;
Rabbits
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of L-arginine (L-Arg) on the arrhythmia induced by ischemia/reperfusion (IR) of the right coronary artery in rabbits. METHODS: 48 healthy adult rabbits were divided into 4 groups (n=12 of each) randomly: IRa group (120 min reperfusion after 30 min ischemia), IRb group (120 min reperfusion after 120 min ischemia), IRa+L-Arg group and IRb+L-Arg group. I/R model was established by occluding and loosening the root of the right coronary artery in rabbits. The changes of ECG and arrhythmia were recorded and graded. RESULTS: ① The longer time of IR was, the higher the score of the arrhythmia was found. The incidence of atrial-ventricular block (AVB), sinus-atrial block (SAB), even sinus arrest were detected and aggravated gradually. ② The incidence of AVB was decreased and from Ⅲ?→Ⅱ?→Ⅰ? markedly, some of sinus and atrial arrhythmia were transformed into sinus rhythm gradually, and all of the arrhythmia scores in IRa group were decreased significantly as compared with the same time phases of IRb group (P
