Effects of IFN-?1b on morphology and the expression of connective tissue growth factor in hepatic stellate cells
- VernacularTitle:IFN-?1b对肝星状细胞形态及其CTGF表达影响的研究
- Author:
Weifeng CHEN
;
Qian WANG
;
Kefei ZHANG
;
Jiefu HUANG
;
Hongxu XU
- Publication Type:Journal Article
- Keywords:
Hepatic stellate cells;
Interferon-alpha;
Connective tissue growth factors
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of (IFN-?1b) on morphology and the expression of connective tissue growth factor (CTGF) in hepatic stellate cells (HSC). METHODS: HSC were cultured in vitro, and were treated with (IFN-?1b) and TGF-?_1. The changes of HSC on morphology were observed, and the expression of CTGF in HSC was assessed using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Phenomenon of apoptosis were observed in HSC treated with IFN-?1b. The expression of CTGF in HSC was decreased after treatment with (IFN-?1b) in control and TGF-?1-triggered groups. CONCLUSION: (IFN-?1b) is able to induce the apoptosis and suppress the expression of CTGF in HSC.
